Buy anti androgens online dating

10-Aug-2020 01:01

The earlier androgen synthesis inhibitors aminoglutethimide and ketoconazole have only limitedly been used in the treatment of prostate cancer due to toxicity concerns and have been replaced by abiraterone acetate.

In addition to active treatment of prostate cancer, antiandrogens are effective as prophylaxis (preventatives) in reducing the risk of ever developing prostate cancer.

Hyperandrogenism is associated with virilization – that is, the development of masculine secondary sexual characteristics like male-pattern facial and body hair growth (or hirsutism), voice deepening, increased muscle mass and strength, and broadening of the shoulders, among others.

Antiandrogens are used to prevent or reverse masculinization and to facilitate feminization in transgender women who are undergoing HRT and who have not undergone sex reassignment surgery or orchiectomy.

The side effects of antiandrogens vary depending on the type of antiandrogen – namely whether it is a selective AR antagonist or lowers androgen levels – as well as the presence of off-target activity in the antiandrogen in question.

For instance, whereas antigonadotropic antiandrogens like Gn RH analogues and cyproterone acetate are associated with pronounced sexual dysfunction and osteoporosis in men, selective AR antagonists like bicalutamide are not associated with osteoporosis and have been associated with only minimal sexual dysfunction.

In women, antiandrogens are much better tolerated, and antiandrogens that work only by directly blocking androgens are associated with minimal side effects.

However, because estrogens are made from androgens in the body, antiandrogens that suppress androgen production can cause low estrogen levels and associated symptoms like hot flashes, menstrual irregularities, and osteoporosis in premenopausal women.

In any case, common side effects of antiandrogens in men include breast tenderness, breast enlargement, feminization, hot flashes, sexual dysfunction, infertility, and osteoporosis.

In women who are pregnant, antiandrogens can interfere with the androgen-mediated sexual differentiation of the genitalia and brain of male fetuses.

This manifests primarily as ambiguous genitalia – that is, undervirilized or feminized genitalia which, anatomically, are a cross between a penis and a vagina – and theoretically also as femininity and homosexuality.

Monotherapy with the nonsteroidal antiandrogen bicalutamide is also used in the treatment of prostate cancer as an alternative to castration with comparable effectiveness but with a different and potentially advantageous side effect profile.

High-dose estrogen was the first functional antiandrogen to be used in the treatment of prostate cancer and was widely employed, but has largely been abandoned for this indication in favor of newer agents with improved safety profiles and fewer feminizing side effects.

In any case, common side effects of antiandrogens in men include breast tenderness, breast enlargement, feminization, hot flashes, sexual dysfunction, infertility, and osteoporosis.In women who are pregnant, antiandrogens can interfere with the androgen-mediated sexual differentiation of the genitalia and brain of male fetuses.This manifests primarily as ambiguous genitalia – that is, undervirilized or feminized genitalia which, anatomically, are a cross between a penis and a vagina – and theoretically also as femininity and homosexuality.Monotherapy with the nonsteroidal antiandrogen bicalutamide is also used in the treatment of prostate cancer as an alternative to castration with comparable effectiveness but with a different and potentially advantageous side effect profile.High-dose estrogen was the first functional antiandrogen to be used in the treatment of prostate cancer and was widely employed, but has largely been abandoned for this indication in favor of newer agents with improved safety profiles and fewer feminizing side effects.These side effects include breast pain/tenderness and gynecomastia (breast development/enlargement), reduced body hair growth/density, decreased muscle mass and strength, feminine changes in fat mass and distribution, and reduced penile length and testicular size.